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Right on South Kingshighway, High Profile Cape Girardeau is an easy stop for the regional hub of Southeast Missouri — locals from around town, Southeast Missouri State students and staff, and neighbors from Jackson and Scott City who are only a few minutes up or down US-61. Just off I-55, it’s a straightforward pull-in whether you’re running errands along Kingshighway or coming off the interstate.
The store sits at the center of a wide stretch of SEMO country, drawing regulars from the smaller towns that ring the city — Dutchtown, Gordonville, Chaffee, and the Scott County communities to the south. Whatever brings you in, the menu covers the full recreational range: flower, pre-rolls, vapes, edibles, and concentrates for adults 21+.
Walk in and a budtender will help you find what you’re after, with daily deals and discounts for students, seniors, and veterans.
With High Rollers Rewards signup
With High Rollers Rewards signup
With valid Med Card
Thank you for your service
Current cannabis industry employees
Active students and staff
Thank you for your service
All customers age 60+
High Profile Cape Girardeau anchors a broad Southeast Missouri service area along the Mississippi River. Jackson is about 10 miles north, roughly a 14-minute drive up US-61, and Scott City sits a quick 12 minutes south. Farther out, the store stays convenient for the wider region: Sikeston is about 34 miles south down I-55 (around 40 minutes), and Perryville is a similar 38 miles north on the interstate. With the store just off I-55 and right on Kingshighway, it’s easy to reach from anywhere in the Cape Girardeau area.
David was great
My go to shop
Love this place receptionist is so nice workers are nice and knowledgeable
My bud tender was amazing and super friendly and he was very knowledgeable
From the front desk to checkout was amazing! Definitely going back very soon!!!
I found my favorite strain, Grape Ape. I've been trying to find it over a few years now.. I'm as happy can be. Thank You High Profile.
Very solid spot! Not the cheapest in town but everything appeared high quality. Caleb took great care of me, can't wait to try his recommendation :)
Great everything
Great Dispensary!! Great experience every time..
At 772 South Kingshighway, Ste 101, Cape Girardeau, MO 63703 — on Kingshighway just off I-55 (Exit 96 / William Street), with on-site parking.
Open Monday through Thursday 8am–9pm, Friday and Saturday 8am–10pm, and Sunday 8am–9pm.
No. Recreational customers 21+ with a valid government-issued ID are welcome.
Yes — the store runs daily deals plus discounts for students, seniors, and veterans.
A full recreational selection — flower, pre-rolls, vapes, edibles, and concentrates across a range of price points.
By selecting 'Yes', you confirm that you are of legal age or a valid medical patient and agree to our Terms and Privacy Policy.
This November, Massachusetts voters will decide the future of legal cannabis in this state.
